Nexus Research

Disclaimer: Please note the below information is for our patients and service users who are interested in the research we are currently participating in. This is not a recruitment page. If appropriate, your GP will invite you to participate in a research study on a case by case basis. It is not possible to request access to a study.

Click on the below titles to find out more 

Clinical research network: South London

Dementia Research is a service which allows people to register their interest in national dementia research.

It helps people with dementia, their carers, or anyone interested in dementia research to be matched to studies. Once registered, your details will be stored securely, and will be regularly checked to see if you match to studies. Find out more here: www.joindementiaresearch.nihr.ac.uk

Bioresouce

Recruit for studies on common diseases, rare diseases and even healthy populations. Due to the specialist work needed to support COVID research we have a special section for that too. We can recall members who wish to take part in further studies. 
Find out more here: www.bioresource.nihr.ac.uk

Aspirin To Target Arterial events in Chronic Kidney Disease (ATTACK)

This study aims to find out whether people with chronic kidney disease (CKD) should take daily low-dose aspirin to reduce the risk of a first heart attack or stroke (cardiovascular disease, CVD).

We want to determine whether aspirin should be given to people with CKD to prevent a first heart attack or stroke (primary prevention). As CVD is more common in people with CKD than in the general population we would expect aspirin to be of greater benefit, but the risks of bleeding may also be higher. Before we can recommend aspirin for primary prevention in people with CKD we need to be sure that the benefits outweigh the possible risks.

Covid-19 vaccines in pregnancy (Preg-CoV)

To recruit, vaccinate and follow-up pregnant women across the UK in order to look at the safety of, and immune responses to, COVID-19 vaccines in pregnant women and their babies.

IMP2ART Cluster Randomised Trial (PG4/5)

Although we know that supported self-management helps people live with their asthma it isn’t widely provided: fewer than 1 in 4 people who replied to an Asthma UK web survey owned an asthma action plan. There are many reasons why self-management is not more widely used. These include:

1) lack of resources available for patients

2) healthcare professionals not possessing the right skills

3) the way that asthma management is organised in the health service.

The IMP2ART programme of work has developed a new approach to target all three areas.

INTERACT: Integrated CBT for depression trial

Multi-centre randomised controlled trial of integrated therapist and online CBT (Cognitive behavioural therapy) for depression in primary care.

*RAPID™ [Restorative Autologous Platelet biotherapies for Injuries & Delayed wound healing] Biodynamic Haematogel.

The primary objective of this pilot study, is to determine safety and efficacy of additional RAPID™ Biodynamic Haematogel (RAPID™ Gel) treatment to usual and customary care, in complete wound healing of chronic diabetic foot ulcers, within 12 weeks.

The CATHETER II Study

Comparing the clinical and cost-effectiveness, patient acceptability and satisfaction, and safety of weekly prophylactic catheter washouts policies in addition to standard LTC (Long Term Catheter) care compared to standard LTC care only

The interventions being compared are:

  • Intervention arm (A): Weekly saline washouts plus standard LTC care.
  • Intervention arm (B): Weekly acidic washouts plus standard LTC care.
  • Control arm (C): Standard LTC care only

Participants are followed-up for 24 months to assess catheter blockages, infections, and complications, plus their quality of life, satisfaction, costs to the participant and NHS. The views, attitudes, experiences and expectations of washouts with participants, nurses, and doctors are explored through an optional qualitative study.

Participants are asked whether they need the help of a relative, friend or other informal carer, who is not a paid healthcare worker or NHS staff, to take part in the CATHETER II study. If they indicate that they need or have help then the study team approaches the identified person to take part also.

LonDownS- The London Down Syndrome Consortium (LonDownS): an integrated study of cognition and risk for Alzheimer's Disease in Down Syndrome

Down Syndrome (DS) occurs due to the presence of three copies of chromosome 21, and is the most common genetic cause of intellectual disability. Individuals with DS show a large variability in their cognitive abilities, and problems may be seen in functions related to frontal, temporal, hippocampal and cerebellar regions (such as executive functioning, language, memory, and motor coordination). All individuals with DS have Alzheimer’s Disease (AD) neuropathology in their brains after the age of 30, yielding a much greater risk for developing the clinical signs of AD compared to the general population. Not all individuals with DS however develop the clinical symptoms of AD. This may be due to differences in their genetic, biological, cognitive or socio-economic profiles, although the contributions of these causes that account for this variation are currently unknown. The proposed study will investigate these variations and their developmental origins.